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KMID : 0380620100420010109
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Korean Journal of Food Science and Technology
2010 Volume.42 No. 1 p.109 ~ p.114
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Effect of Anti-atopic Allergic Reaction in Response to Oriental Herb Extracts
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Yang Hee-Jin
Park Ki-Moon
Park Kye-Won
Kim Hyun-Suck
Cho Soo-Muk
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Abstract
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The in vivo and in vitro effects of oriental herb extracts of Cassia obtusifolia, Taraxacum platycarpum and Ulmusmacrocarpa on anti-atopic allergic reaction were evaluated in this study. A mixture of these extracts exhibited more potent anti-allergic activities in human mast cells than those from individual extracts. The herbal mixture significantly inhibited the release of compound 48/80-induced β-hexosaminidase release in the human mast cell line, HMC-1. The mixture also suppressed the production of PMA and A23187-induced inflammatory cytokines in HMC-1 cells. To further investigate the in vivo effects of the herbal mixture, a Dermatophagoides farinae (DF)-induced atopic dermatitis mouse model was utilized. Oral administration of the herbal mixture significantly decreased the ear thickness and swelling in DF treated NC/Nga mice in a dose dependent manner. Furthermore, serum levels of IgE and interleukin-4 (IL-4) were significantly decreased, whereas interferon-gamma (IFN-γ) levels were increased in the mixture administrated groups when compared to the control. Taken together, our data indicate the possibility of using a mixture of the oriental herb extract to relieve symptoms of atopic dermatitis.
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KEYWORD
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Cassia obtusifolia, Taraxacum platycarpum, Ulmus macrocarpa, anti-atopic allergic reaction
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